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우무가사리(Gelidium amansii)의 驅蟲成分에 對하여(第1報)

Studies on the Anthelmintic constituents of Gelidium amansii

약학회지 1962년 6권 2호 p.1 ~ 6
서석수, 홍승철,
소속 상세정보
서석수 (  ) - Pusan National University College of Pharmacy
홍승철 (  ) - Pusan National University College of Pharmacy

Abstract


Clinical tests revealed that the extracts of of Gelidium amansii (Gelidiaceae) had a anthelmintic action and further examinations were made on the anthelmintic components of this seaweed.
This anthelmintic principle is adsorbed on alumina and eluted from it by alkali solution. Tho active principle is adsorbed on activated carbon from aqueous extract and eluted from it by methanol and it is not adsorbed on Amberite IR-120(H-form). This anthelmintic effective fraction was prepared by the use of this properties.
Action of the active principle of Gelidiun amansii was examined pharmacologically. The active principle of Gelidium amansii was found to decrease the tensity, tonus and mobility of Eisenia foetida.(Savigny) nerve muscles.
The active principle of this effective fraction was submitted to paper chromatography and spots to ninhydrin were detected at Rf; 0.30~0.31(yellow), 0.26(violet), 0.2(violet), 0.14~0.13(violet), 0.9(orange) and 0-04(violet).
(Received April 7. 1962)

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