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Alkyl 及 Aryl thionocarbamate類의 合成과 그 驅蟲作用에 關한 硏究

Preparation of Alkyl and Aryl-thionocarbamate and their Anthelmintic action

약학회지 1963년 7권 2호 p.58 ~ 66
국채호,
소속 상세정보
국채호 (  ) - Seoul National University College of Pharmacy

Abstract


Alkyl-phenylthionocarbamates already have been investigated as anthelmintics. Especially ethyl-phenylthionocarbanlate is noted for its anthelmintic action. Author studied methods for synthesizing Alkyl-phenyttsonocarbamates, Alkyl-p-phenetyl thionocarbamates, Alkyl-cyclohexylthionocarbanlates, 5 kinds for each. For alkyl radical -CH_(3), -C_(2)H_(5), -n-Propyl, -isobuthyl, -n-buthyl, being chosen. Compounds Ⅶ, X, XIII, XIV, and XV are new compounds. At the sametime author prepared 4 kinds of Arylthionocarbamates, among which XVII, and XIX being new compounds. (Table Ⅰ) The anthelmintic action of these thionocarbamates has been examined through kymographic records indicating the action of neuromuscular preparation of Eisenia foetida Savigny in the various concentration fo above compounds:-Trendetenburg method. Santonine as the criterion of the estimation. (Tabte. Ⅱ) 1. Compounds I-X could be prepared by method A or method B. method A in sealed tube brought on better yield and purity. 2. Compounds XI-XV could´nt be prepared by method A but by method B. 3. Arylthionocarhamates XVI, XVII, XVIII, and XIX Could´nt be prepared by method A or method B but by method C. 4. Analyzed N. contained in all compounds. Analyzed C.H. and N. contained in unknown compounds, VIII, Ⅹ, XIII, XIV, XV, XVII.,and XIX. 5. Eramination of anthelmintic action has been done under the advice of Prof. J.S. Oh medical college, Seoul Nat. University. 6. Compounds VI-X showed little action. 7. Compounds XVI-XIX showed almost no action. 8. Compounds XI-XV showed stronger action than compounds Ⅰ-Ⅴ, which was reported already as a usable anthelmintics. 9. Compounds XI, XII, XIII and XIV showed strongest actions, stronger than santonine as recorded on kymographion of the Trendelenburg method. Provided that, the toxify of theie compounds found mild enough for human system, these compounds will serve as anthelmintics of greater powers than compounts Ⅰ-Ⅴ. 10. In Alkylthionocarbamates, R´NH-radical more influence on the anthelmintic action than ester radical (-OR)

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