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시메티딘과 이소니아짓의 약물 상호작용

Drug Interaction of Cimetidine and Isoniazid

약학회지 1988년 32권 5호 p.319 ~ 327
이종기, 최봉남, 최준식,
소속 상세정보
이종기 (  ) - 조선대학교 약학대학
최봉남 ( Choi Bong-Nam ) - 조선대학교 약학대학
최준식 (  ) - 조선대학교 약학대학

Abstract


Pharmacokinetic interaction of cimetidine and isoniazid was investigated in the rabbits. Isoniazid was administered orally at a dose of 30mg/kg to six rabbits after 10, 20, and 30mg/kg pretreatment of cimetidine twice a day for 10days. Concentration of the free and the total isoniazid in the blood and the urine was determined by spectrophotometer. Relative bioavailability and biological half?life(t4p) were increased significantly by cimetidine pretreatment. Overall elimination rate constant . and total clearance of isoniazid were decreased significantly by cimetidine pretreatment. The ratio of metabolites to isoniazid in the blood and the urine was decreased significantly by cimetidine pretreatment. Relative bioavailability, INAH to metabolites ratio in the blood and decrease in total clearance were highly correlated with the does of cimetidine pretreated. This result might be due to the inhibition of isoniazid metabolism in the liver by cimetidine pretreatment.

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