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금은화(Lonicerae Flos)의 Ethyl Acetate 분획이 돌연변이원성에 미치는 영향

Effects of Lonicerae Flos´ Ethyl Acetate Fraction on Mutagenicity

약학회지 1988년 32권 5호 p.328 ~ 333
장무웅, 권동렬, 백석환, 김성환, 김태완,
소속 상세정보
장무웅 (  ) - 영남대학교 약학대학
권동렬 (  ) - 영남대학교 약학대학
백석환 (  ) - 영남대학교 약학대학
김성환 (  ) - 영남대학교 약학대학
김태완 (  ) - 영남대학교 약학대학

Abstract


Based on the following tests with fractions extracted from organic solvents such as benzene, chloroform, ethyl acetate and methanol, this study is to analyse the antimutagenicity of Lonicerae Flos. When carrying out Ames test with Salmonella typhimurium strain, it seemed that there was stronger antimutagenicity in TA 100 treated by MNNG than did one in TA 98 by NPD, and that there was stronger antimutagenicity through base pair exchange than one through frame shift. In the umu test, each fraction tended to inhibit the activity of p-galactosidase induced by AF-2. As shown in these above tests, the ethyl acetate fraction was the strongest among four fractions. On the other hand, its component consisted of luteolin, apigenin, chlorogenic acid and five unknown ingredients. Of these unknown ingredients, E, F strongly tended to inhibit the activity of p-galacosidase. In addition,there was also the decrease in its activity of apigenin, luteolin and chlorogenic acid.

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