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1-β-D-Arabinofuranosylcytos의 Prodrug 연구

Study on Prodrugs of 1-β-D-Arabinofuranosylcytosine

약학회지 1988년 32권 5호 p.334 ~ 339
이희주, 김태련,
소속 상세정보
이희주 (  ) - 덕성여자대학교
김태련 (  ) - 덕성여자대학교

Abstract


AraC-5´-methylthioacetate (araC-MTA, 1) and araC-5´-butylthioacetate (araCBTA, 2) were prepared and their physical and chemical properties and in vivo antitumor activities were examined. Both compounds were found to have higher partiton coefficients (n-hexanol/water) than their parent araC and to be hydrolyzed to araC within an hour in mouse plasma and ascitic fluid solutions. In in vivo antitumor activity test they showed similar potency to araC, which were assumed due to too quick hydrolyses of them to parent in the body fluid.

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