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Ibuprofen의 합성

Synthesis of Ibuprofen

약학회지 1988년 32권 5호 p.340 ~ 342
최홍대,
소속 상세정보
최홍대 (  ) - 동의대학교 화학과

Abstract


New synthetic method for ibuprofen, which is a potent antiinflammat° ry agent, was described. Ethyl a-methylthio-p-isobutylphenylacetate was obtained from Friedel-Crafts reaction of isobutylbenzene with ethyl a-chloro-a-(methylthio)acetate in the presence of SnC14. Ibuprofen was prepared in good yield by treatment of ethyl a-methylthio-p-isobutylphenylacetate with NaH and Mel, followed by desulfurization with zinc dust-acetic acid and hydrolysis of the resultant ethyl 2-methylthio-2-(4-isobutylphenyl)propionate.

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