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항 결핵제, 리팜피신에 내성인 유산균의 개발

Development of Lactobacillus casei Resistant to Rifampicin, an Antituberculosis Agent

약학회지 1988년 32권 6호 p.394 ~ 401
이승희, 서진호, 박천호,
소속 상세정보
이승희 (  ) - 서울대학교 약학대학
서진호 (  ) - 서울대학교 약학대학
박천호 (  ) - 서울대학교 약학대학

Abstract


Lactobacillus casei was treated with N-methyl-N´-nitro-N-nitrosoguanidine(NTG) to obtain resistant mutants to rifampicin. Freshly grown cells of the strain suspended in tris-maleic acid buffer were exposed to NTG of 50pg/ml for 30min. Five colonies of the NTG-induced mutants showed distinct resistance to rifampicin. They also exhibited identical characteristics with the original Lactobacillus casei when they were tested for growth, titrable acidity and sugar fermentation. It is suggested that they can be utilized as efficieient starter cultures for fermented milk.

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