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3-Methylcholanthrene을 注射한 惡性腫瘍患者의 尿中 17-Ketosteroid와 17-Hydroxy-Corticosteroid의 排泄量에 對하여

Urinary Excretion of 17-Ketosteroid and 17-Hiydroxycorticosteroid after the Injection of Patients with Malignant Neoplasm using 3-Methylcholathrene

대한외과학회지 1962년 4권 8호 p.555 ~ 559
석세일,
소속 상세정보
석세일 (  ) - 서울대학교 의과대학 외과학교실

Abstract


Urinary excretion of 17-Ketosteroid and 17-Hydroxycorticosteroid was estimated weekly for a period of three weeks on eight hospital patients with various types of malignant neoplasms, to whom 20 mg-of 3-Methylcholanthrene was given intramuscularly daily.
The excretory pattern of both steroids was nearly the same. Gradual decrease of urinary excretion was found in the early period (one week after the injection of 3-Methylcholanthrene, followed by a continuous decrease except in two cases. One of these exceptions showed a gradual increase and the other returned to the original value.
It is assumed from this study that there might be a certain relationship between retardation or regression of the growth of malignant neoplasms and the indirect or diract deppressive influence to the adrenal cortex with the injection of 3-Methylcholanthrene.

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