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Clinical impact of sarcopenia in patients with colon cancer undergoing laparoscopic surgery

Annals of Surgical Treatment and Research 2020년 99권 3호 p.153 ~ 160
오락균, Ko Hye-Mi, 이정은, 이경하, 김지연, 김진수,
소속 상세정보
오락균 ( Oh Rak-Kyun ) - Chungnam National University College of Medicine Department of Surgery
 ( Ko Hye-Mi ) - Chungnam National University College of Medicine Department of Surgery
이정은 ( Lee Jeong-Eun ) - Chungnam National University College of Medicine Department of Radiology
이경하 ( Lee Kyung-Ha ) - Chungnam National University College of Medicine Department of Surgery
김지연 ( Kim Ji-Yeon ) - Chungnam National University College of Medicine Department of Surgery
김진수 ( Kim Jin-Soo ) - Chungnam National University College of Medicine Department of Surgery

Abstract


Purpose: Previous studies have reported that progressive muscle loss, known as sarcopenia, has a negative impact on colon cancer treatment. However, the majority of studies have analyzed on patients undergoing open resection, and the association of sarcopenia with clinical outcomes is not clear for patients with colon cancer undergoing laparoscopic surgery. Thus, the aim of this study was to evaluate the impact of sarcopenia on clinical outcomes after laparoscopic surgery for colon cancer.

Methods: A total of 423 patients who underwent laparoscopic surgery for colon cancer between November 2010 and October 2014 were included. Body composition was assessed by measuring muscle and fat areas at the third lumbar vertebra (L3) on preoperative computed tomography. The L3 skeletal muscle area was used to calculate the skeletal muscle index and to assess for sarcopenia.

Results: Sarcopenia was identified in 54 patients (12.8%). The median time to first flatus (3 days), median time to tolerable soft diet (4 days), and median length of hospital stay (7 days) were not significantly different between patients with and without sarcopenia. However, sarcopenia was an independent risk factor for postoperative complications in the logistic regression multivariate analysis (P = 0.015). Sarcopenia was not associated with overall or disease-free survival.

Conclusion: Sarcopenia was not negatively associated with functional recovery, hospital stay, and oncologic outcomes in patients with colon cancer who underwent laparoscopic surgery. However, sarcopenia was associated with postoperative complications after laparoscopic surgery for colon cancer.

키워드

Colonic neoplasms; Laparoscopy; Prognosis; Sarcopenia

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