잠시만 기다려 주세요. 로딩중입니다.

Antithrombotic therapy has no beneficial effect in conservative treatment of spontaneous isolated superior mesenteric arterial dissection

Annals of Surgical Treatment and Research 2021년 100권 3호 p.166 ~ 174
손대경, 최수진나, 이호균,
소속 상세정보
손대경 ( Sohn Dae-Kyung ) - Chonnam National University Medical School Department of Surgery
최수진나 ( Choi Soo-Jin-Na ) - Chonnam National University Medical School Department of Surgery
이호균 ( Lee Ho-Kyun ) - Chonnam National University Medical School Department of Surgery

Abstract


Purpose: Initial conservative treatment with selective endovascular or surgical intervention has shown successful outcomes in the treatment of spontaneous isolated superior mesenteric artery dissection (SISMAD). However, the benefits of antithrombotic therapy as a part of conservative treatment have not been clarified. This study aimed to investigate the clinical course of SISMAD patients and determine differences in clinical outcomes between the antithrombotic and no-antithrombotic groups.

Methods: We retrospectively reviewed 79 cases of SISMAD that were treated conservatively from January 2004 to December 2019 at Chonnam National University Hospital. Clinical outcomes, including the length of hospital stay, pain resolution time, image remodeling, and maximal remodeling time, were compared between the antithrombotic and no-antithrombotic groups.

Results: There were 30 patients in the no-antithrombotic group and 49 patients in the antithrombotic group. There was no significant difference in clinical characteristics between the 2 groups, except for dyslipidemia (P = 0.011). The follow-up period (32.6 months vs. 14.6 months, P = 0.009) and imaging follow-up period (31.6 months vs. 13.9 months, P = 0.011) were longer in the antithrombotic group than in the no-antithrombotic group. The length of hospital stay (5.1 days vs. 7.7 days, P = 0.002) was significantly shorter in the no-antithrombotic group than in the antithrombotic group because patients in the antithrombotic group required longer hospitalization for warfarin titration.

Conclusion: In patients with SISMAD, conservative treatment without antithrombotic therapy may have clinical benefits such as decreased length of hospital stay compared with conservative treatment with antithrombotic therapy.

키워드

Antithrombotic agent; Conservative treatment; Remodeling; Spontaneous isolated superior mesenteric artery dissection

원문 및 링크아웃 정보

 

등재저널 정보