Studies on the Preparation of Radioactive Iodine Labelled Concanavalin-A, Lectin Extracted from Korean Native Plant "Banha", and Their Conjugation Products and the Hemagglutination Tests of These Labelled Compounds in Vitro
원자력학회지 1978년 10권 1호 p.1 ~ 12
김유선, 박경배,
소속 상세정보
김유선 ( Kim You-Sun )
Radio Organic Chemistry Lab. Korea Atomic Energy Research Institute
박경배 ( Park Kyung-Bae )
Radio Organic Chemistry Lab. Korea Atomic Energy Research Institute
KMID : 0371819780100010001
Abstract
Concanavalin-A, 한국산 반하(半夏)로부터 주출된 Lectin 및 이들과 tyrosine 또는 5-iodo-6-aminouracil을 결합시킨 화합물들을 각각 방사성 요오드-125로 표지하였으며 표지된 화합물들을 사용하여 생채외부 시험법으로 혈액응고 시험을 실시하였다. 표지반응에 관하여 표지수율과 함께 그 실험조건을 보고하였으며 Lectin과 여러 아미노산계통 화합물들과의 결합반응성을 논의하였다. 암세포에 대한 혈액응고 시험결과를 보고하였으며 이들 표지화합물들의 임상적 실용전망에 관하여서도 논의하였다.
Concanavalin-A, lectin extracted from Korean native plant "Banha" (Pinellia Ter rata) and their conjugation products with tyrosine and 5-iodo-6aminouracil were labelled by radioactive iodine-125, and these labelled compounds were subjected to a hemaggIutination test in vitro. The labelling procedures were presented with respect to labelling yield and the trends on the conjugation reaction of lectin with various amino acids were discussed. The preliminary results on the hemagglutination tests against cancer tissues were presented and the potential clinical applications of these labelled compounds were discussed.
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