백서에 있어서 Hepatic Microsomal Cytochrome P-450에 대한 Diazepam, Cimetidine 및 Sulpiride의 영향
Influence of Diazepam, Cimetidine and Sulpiride on the Level of Hepatic Microsomal Cytochrome P-450 in Rats
이화의대지 1979년 2권 3호 p.161 ~ 164
김복희, 함윤애, 최광식, 윤하나,
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김복희 ( )
이화여자대학교 의과대학 생화학교실
함윤애 ( )
이화여자대학교 의과대학 생화학교실
최광식 ( )
이화여자대학교 의과대학 생화학교실
윤하나 ( )
이화여자대학교 의과대학 생화학교실
KMID : 0374019790020030161
Abstract
Cytochrome P-450 is a terminal oxidase of the hepatic microsomal monooxygenase system associated with the oxidative biotransformation of a varity of lipophilic endogenous and exogenous compounds, and generally is assayed by CO-binding spectro-photometry of dithionite-reduced samples.
In well-fed normal male rats with or without stress condition, the effect of antiulcerdurg; cimetidine, sulpiride and diazepam on the level of microsomal cytochrome P-450 were determined. Only stress condition produced no significant effect in cytochrome P-450 contents. Administration of cimetidine, sulpiride and diazepam in this condition caused a 44.1%~87.5% increment in cytochrome P-450, diazepam produced the most increase. After diazepam treatment of rats, the peak position of cytochrome P-450 shifited to a longer wave length of 452 nm.
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