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자라腸片의 연動運動에 關한 硏究

The Peristaltic Movement of the Tortoise Intestine

전남의대잡지 1964년 1권 2호 p.157 ~ 166
차석균,
소속 상세정보
차석균 (  ) - 전남대학교 의과대학 약리학교실

Abstract


The peristaltic movement of th intestine of the tortoise(Amyda japonica)was investigated by the method of Trendelenburg or Belesin and Varagic. 1) The intraluminal pressure(up to 8CmmH₂O)did not induce the peristalsis. The simultaneous applications of the pressure and 5-hydroxytrytamine on the mucosal surface also failed to induce the peristaltic movement. The intraluminal application of huge doses of acetylcholine(1mg/ml), when applied together with the pressure, caused very weak peristalsis. 2) The addition of 5-hydroxytrytamine or acetylcholine(as low as 0.01㎍/ml) into the bath (i.e., application on the serosal surface)with intraluminal pressure caused distinct peristaltic movements, The development of the peristaltic activity was not prevented by a local anesthetic, etracaine. 3) DMPP and BaCl₂, Which produced contratile responses in the tortoise intestinal strip, did not cause peristaltic movement either by applying to the serosal or mucosal surface. As 5-hydroxytrytamine, shich ineffective to cause conractile response in the Magnus preparation of the tortoise intestine, produced the peristaltic movement as described above, the difference of the responses of the longitudinal and circular strip of the tortoise intestine was examined. 4) 5-hydroxytrytamine caused prominet contraction of the circular strip without exerting any effect on the longitudinal strip. The contration was blocked by deseril but not by morphine or teracaine. 5) To Acetycholine and BaCl₂the both strip reacted with contractions, to DMPP the longitudinal strip reacted with contration but the circular one did not. Histamine produced little effect on either strip. 6) From the above results it could be concluded that the nature of the peristaltic activeity of the tortoise intestine seemed to be different from that of mammalians. In addition the difference in the response of the longitudinal and the circular coat to certain pharmacological agents could be observed.

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