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THE PHARMACOLOGICAL RESFOSES OF THE CIRCULAR AND LONGITUDINAL MUSCLE OF THE ISOLATED RABBIT COLON

Ǵ 1964 1 2ȣ p.205 ~ 217
Kim Yung-Yul,
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 ( Kim Yung-Yul ) - Chonnam National University Medical School Department of Pharmacology

Abstract

ɰ 䰡 ˷ ִµ (Brownlee and Harry, 1963), ʫ̿ Ͽ Ҵ. Magnus۰綿 Ͽ κϿ, 3mm ̸ ϸ Ͽ κϿ. ̿
1) acetlrlcholine, Morepinephrine, Pilocerpine, Histamino, DMPP Ͽ ϰ,
2) 5-HT(5-Hydroxytryptamine) Ͽ ̳ Ѧ ٸ Ҵ. Methylatropine, Hexametaium, Deseril dz, Morphne, Tetracaineδ Ͽ, Morphine, Trtracaine, Drseril ϵ Mettylatropine, Hexamethoniumδ ġ ƴϿ.
3) ҭ ˿ McN-A-343 AHR-602 Ͽ Ͽ. AHR-602 Ͽ ϳ, McN-A-343 ῡ 춰 ־ ֿ , ֿ . ̸ Methyratrcpine ǿ.
4) Scolamire McN-A-343 Ƶ Bretylium dz, Bretylium, Hexamethoniumδ ƴϿ.
5) Scopolamine Acetylcholine ɿ ʾ Ͽ. ̴ Hexamethonium Bretylium Ǿ.
߾ ̷ ʫ̿ 䰡 ־, Brownlee and Harry(1963) 󿡼 Ѱó Ѵٱ ٴ ʫ̿󿡼 .
Employing a preparation of the circularmuscle strip of the rabbit colon, its pharmacological responses were compared with those of the longitudinal muscle. The responses to acetylcholine, norepinephrine, pilocarpine .histamine and DMPP were not different.
The effect of 5-hydroxytryptamine was a contraction in both muscles, but the nature of the contraction seemed to be different the response of the circular muscle was competitively blocked by methylatropine, hezamethonium and deseril and little affected by morphine and tetracaine; those of the longitudinal muscle was competitively blocked by morphine, tetracaine and deseril and little affected by methylatropine and hexamethonium.
Both McN-A-343 and AHR-602 produced contractions of the circular muscle. The longitudinal muscle was always contracted-by AHR-603, but its response to McN-A-343was varied with doses; generally a relaxation with low doses and a contraction with higher doses. The contraction Induced by AHR-602 or McN-A-343 was effectively blocked by methylatropine.
McN-A-343 produced always a relaxationi the presence of methylatropine or scopolamine, which was blocked by high doses of brety]ium, but not by hexamethonium or lower doses of bretylium. Huge doses of acetylcholine also produced a relaxation in the presence of high doses of scopolamine which was blocked by hexarnethoiliurn and lower doses of bretylium.
The main differences in the responses of the circular and longitudinal muscle of the rabbit colon to drugs seems to be in the nervous structures associated with the muscles.

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