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交感神經節興奮劑에 對한 剔出자라心房의 反應

Responses of Isolated Tortoise Atria to Sympathetic Ganglionic Stimulants

전남의대잡지 1967년 4권 1호 p.1 ~ 10
황종규,
소속 상세정보
황종규 (  ) - 전남대학교 의과대학 약리학교실

Abstract


The effects of nicotine, DMPP, and AHR-602 were studied in isolated tortoise atria preparations. The influence of various blocking agents on the responses to these agents also was studied.
Nicotine and DMPP produced augmentative responses preceded by inhibition. AHR-602 produced inhibitory responses, but produced augmentative responses in the presence either of atropine or physostigmine.
The augmentative responses to these agents were blocked by nethalide, guanethidine, and cocaine. Reserpine pretreatment greatly reduced the augmentative responses to these agents. Hexamethonium or hemicholinium with vagal stimulation blocked the responses to nicotine and AHR-602 in the presence of physostigmine, but had no effect on the responses to DMPP and AHR-602 in the presence of atropine.
Possible mechanisms concerning the action of nicotine, DMPP, AHR-602 in the presence of physostigmine or atropine are discussed in the light of the effects of the pharmacologic blocking agents used.

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