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5-Hydroxytryptamine과 Sympathomimetic Amine에 依한 不整搏動 및 이에 미치는 Quinidine의 影響

Arrhythmia Produced by Combined Actions of 5-Hydroxytryptamine and Sympathomimetic Amines and Effect of Quinidine on it

전남의대잡지 1967년 4권 1호 p.71 ~ 79
최동주,
소속 상세정보
최동주 (  ) - 전남대학교 의과대학 약리학교실

Abstract


In urethane-anesthetized rabbits, intravenous 5-HT preceded by intravenous sympathomimetic amines produced ectopic beats. No intimate relationship was found between incidence of arrhythmia and the reflexive cardiac slowing produced by 5-HT. This suggested a direct action of 5-HT on heart to produce the ectopic beats.
Intravenous or intraventricular quinidine did not prevent the arrhythmia produced by combined actions of 5-HT and sympathomimetic amines, but exacerbate it in some instances. Quinidine produced a transitory depressor response in normal anesthetized rabbits, whereas it produced pressor response preceded by depression in reserpine-treated rabbits. This suggested some pharmacologic actions of quinidine might be related to sympathetic activity.

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