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骨瑞軟骨板移植의 實驗的 硏究

An Experimental Study on Transplantation of Epiphyseal Plates

전남의대잡지 1968년 5권 2호 p.275 ~ 294
윤재용,
소속 상세정보
윤재용 (  ) - 전남대학교 의과대학 해부학교실

Abstract


Growth potential of epiphyseal plate was investigated in young rabbit, in which transplantation of the distal ulnar epiphysis was performed by autograft, homograft intraperitoneally preserved homograft and osseous union and growth were studied after removal of the plate without transplantation. Histological, histochemical, radiological and autoradiographic examination of- the epiphysis treated as above gave the following results;
1. In the autografted epiphyseal cartilaginous plate, intracartilaginous ossification could be observed from 3 weeks after transplantation, resuming thereafter normal bone formation, while in that of homograft the growth observed at the earlier -period turned eventually to regress so that by 8 to 10 weeks after graft could ´be noted complete. resorption with cessation of growth.
2. In groups where the plate was removed with no graft, osseous union between epiphyseal , and diaphyseal portion could be confirmed by 2 to 3 weeks after graft. No further growth could bee demonstrated after union.
3. Observation of the intraperitoneally stored, autograft confirmed that the plate preserved, the original morphological characteristics for 2 to 3 weeks, thereafter exhibiting new bone formation for 8 weeks following transplantation in abdominall cavity. The homograft of the intraperitoneally stored for 3 weeks prolonged the period of ossification until 10 weeks in contrast to that of immediate homograft in which it lasted only 5 weeks. But these also eventually resulted in gradual progressive resorption.
4. Tritiated thymidine could be labelled in the proliferating layer andteriosteal cells in normal rabbit epiphysis. The homograft of this labelled proliferative layer effected coincidental labelling of hypertrophic layer, whereas the homograft of non-labelled plate into the host epiphysis pretreated with tritiated thymidine showed that the host periosteal cell migrated close to, but not into the grafted epiphysis.
It could be evidenced by the above experiment using normal rabbit ulnar epiphyseal plate that the autograft resumed the growth potential in the new bed, while the homograft of both direct and intraperitoneally preserved showed cessation of ossification and growth. Plausible explanation for this resorption is that the delayed immunological reaction resulted in different rejection in these two groups. It caii also reasonably be-stated that clinical application of autograft of epiphyseal plate is recommended, although practical aspect such as range of graft and accuracy of fixation is-worthy of further experiment.

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