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脊髓離斷 및 中樞興奮이 몇가지 昇壓物質의 效果에 미치는 影響

Influence of Cord-section and Central Stimulation on Effect of Various Pressor Substances.

전남의대잡지 1968년 5권 2호 p.349 ~ 358
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김이기 (  ) - 전남대학교 의과대학 내과학교실

Abstract


Pressor effect of various agents (tyramine, guanethidine, DMPP and. McN-A-343) was compared in whole rabbit, spinal rabbit and nikethamide-treated rabbit. The results were as follows:
1. Guanethidine and McN-A-343 did not elicit pressor´response in whole rabbit, but they elicited pressor response in spinal rabbit.
2. The pressor response to tyramine was more pronounced in spinal rabbit than in whole rabbit.
3. The pressor response,of JB-516-treated rabbit to guanethidine and of cl lorisondamine-treated rabbit to McN-A-343 was less in spinal rabbit than in whole rabbit.
4. During central stimulation´ achieved by nikethamide administration, the pressor response to tyramine, guanethidine, DMPP- and McN A-313 was significantly reduced. After administration of amphetamine, reduction off pressor response to tyramine and DMPP was observed.
5. From these data it was inferred thatt release of physiological neuror transmitter from the sympathetic nerve ending in rabbit seems to be controlled by the center.

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