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자라의 腎臟機能에 미치는 數種 利尿劑의 作用

Actions of several diuretics on the renal function of the tortoise(Amyda japonica)

전남의대잡지 1968년 5권 2호 p.395 ~ 405
이경석,
소속 상세정보
이경석 (  ) - 전남대학교 의과대학 약리학교실

Abstract


In view of the fact that the tortoise (Amyda japonica) possesses a kidney markedly different from those of mammals, both morphologically and func tiorially, the actions of several patent diuretics were investigated in this species.
Organomercurial diuretic, mersalyl and mercurophylline, could not induce; diuresis, nor natriuresis, nor kaluresis in this animal. Mersalyl, on the, contrary, elicited antidiuresis by lowering blood pressure due to its cardiotoxicity.
Ethacrynic acid produced marked diuresis, natriuresis and kaluresis, and increased osmotic clearance with concomitant decrease in free water clearance. These responses result from its inhibitory action of electrolyte reabsorption in the tubules, both proximal and distal, and not from the hemodynan is changes in the glomeruli. It may be inferred that, Henle´s loop and the countercurrent arrangement of tubules are not essential in the action of the diuretic in mammals.
Furosemide, a new potent diuretic of sulfonamide derivative, could unfold its action, closely resembling to that of ethacrynic acid, the only difference being, the depression of clearance of PAH by furosemide.
Superimposing the other diuretic after one has exhibited its full diuretic action didt not produce further increment in diuresis, thus indicating the same sites of action for both agents.

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