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자라에 있어서 Ethacrynic acid 利尿作用에 미치는 Mercurophylline의 影響

Influence of Mercurophylline on the diuretic action of Ethacrynic acid in the tortoise

전남의대잡지 1968년 5권 2호 p.475 ~ 478
최상기,
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최상기 (  ) - 전남대학교 의과대학 약리학교실

Abstract


In view of reports by many authors that ethacrynic acid and mercurial diuretic have a common mechanism and sites of action in the nephron, it was investigated in present study whether a mercurial diuretic, Mercurophylline, which has been shown to be in effective in the tortoise, affects the effectiveness of ethacrynic acid.
It was found that mercurophylline administered either in advance or after ethacrynic acid did not influence the diuresis induced by the latter. Thus it seems unlikely that both agents combine to the same "receptor" site in the tubules of tortoise.

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