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자라에 있어서 Ethacrynic Acid 利尿에 미치는 Dimercaprol의 影響

Influence of Dimercaprol on the diuresis induced by Ethacrynic acid in the tortoise

전남의대잡지 1968년 5권 2호 p.479 ~ 481
이경석,
소속 상세정보
이경석 (  ) - 전남대학교 의과대학 약리학교실

Abstract


This study was, undertaken to investigate whether the diuretic action of ethacrynic acid in the tortoise is based on the inhibition of protein-bound sulfhydryl group in the tubule, as suggested by several authors. Dimercaprol, which inhibits the diuresis as well as toxic -action of mercurial diuretics by freeing inhibited sulfhydryl groups, was shown not to block nor modify the diuresis induced by ethacrynic acid. From this data and other observations, it inay be concluded that the diuretic action of ethacrynic acid is not related to the inhibition of sulfhydryl group in the tubules.

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