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剔出자라心房에 있어서의 Hemicholinium의 作用

Hemicholinium on the Isolated Atria of the Tortoise

전남의대잡지 1969년 6권 1호 p.109 ~ 112
최승구,
소속 상세정보
최승구 (  ) - 전남대학교 의과대학 약리학교실

Abstract


In the isolated vagus-atrial preparations of the tortoise the effects of hemicholinium on the inhibitory responses of the atria to the vagal stimulation, 5-hydroxytryptamine, histamine, dimethylphenylpiperazinium, nicotine, and acetylcholine were studied. Exposure of the preparations to hemicholinium without vagal stimulation produced marked diminution of the inhibitory response to 5-hydroxytryptamine without affection the response to other inhibitory agents. The inhibitory responses to the vagal stimulation were gradually decreased when the stimulations were reeated. When the vagal effect was decreased in the presence of hemicholinium, the inhibitory response to dimethylphenylpiperazinium and nicotine was decreased but the inhibition due to histamine and acetylcholine was not affected. These data indicate that the mechanisms of inhibitory responses to histamine and 5-hydroxytryptamine were different and not associated with the acetylcholine release.

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