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Chloramphenicol의 投與에 依한 貧血의 發生에 關한 實驗的 硏究

Experimental Studies on the development of anemia induced by chloramphenicol

전남의대잡지 1969년 6권 1호 p.119 ~ 127
김규담,
소속 상세정보
김규담 (  ) - 전남대학교 대학원

Abstract


Large amount of chloramphenicol (200 mg./kg./day) was given to therabbits intramusculary for ten weeks, and anemia was induced experimentally. Hematologic features´-and changes of the reticulo-endothelial organs, as well as the :disappearance rate of plasma radioactive irons (Fe-5-9) from the circulating blood and the uptake rate of them in -the various organs were examined. The results are as follows.
1. Red blood cells, hematocrit and hemoglobin of the experimental animals wexe generally decreased.
2. In the experimental, group, reticulocytes were slightly increased. Total number of leukocytes revealed no changes even though pseudoeosinophilic leukocytes were decreased and, lymphocytes increased.
3. The spleen was considerably enlarged but no changes of the liver was noticed in the experimental group.
4. Disappearance rate of plasma radioactive iron from circulating blood was relatively retarded in the experimental group.
5. Fragility test of red blood cell showed no marked difference between the control, and the experimental group.
6. The uptake rate of plasma radioactive iron in various organs, indicated that the absorption-activities of the liver spleen and bone marrow were decreased especially those of spleen were markedly decreased.
7. Microscopical findings revealed increased Kupffer s cells in the liver, proliferative features of reticulo-endothelial cells and atrophied lymph follicles in the spleen, and no specific changes were observed in the bone marrow.

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