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Stop-flow方法으로 分析한 Pyrazinamide의 尿中 排泄機轉

Stop-flow Analysis of urinary excretion of Pyrazinamide in the dog.

전남의대잡지 1969년 6권 3호 p.469 ~ 472
국영종,
소속 상세정보
국영종 (  ) - 전남대학교 의과대학 약리학교실

Abstract


The mechanism of urinary excretion of pyrazinamide, an antituberculous agent, was investigated by means of stop-flow technique in this study, and it was found that pyrazinamide filtered in thee glomeruli is largely reabsorbed in all portions of the tubules. All evidences indicate that the reabsorptive process of pyrazinamide is passive, limited only by concentration gradient. No clue for active process either secretory or reabsorptive, nor for facilitated diffusion was obtained. Pyrazinamide seems to be freely diffusible into the tubular epithelium like urea.

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