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Estradiol-17β와 腦燐脂質의 合成

Effect of Estradiol-17β on the Incorporation of ^(32)P-orthophosphate into Phosphatides of Rabbit Cerebral Cortex

전남의대잡지 1970년 7권 1호 p.63 ~ 65
김용태,
소속 상세정보
김용태 (  ) - 전남대학교 의과대학 생화학교실

Abstract


After incubation of rabbit brain cortex slices with ^(32)P-oithophosphate in Krebs-Ringer Tris(hydroxymethyl) aminotnethane medium, pH 7.4, containing glucose, the phosphatides were separated, by thin-layer chromatography.
In the absence of estradiol -17β, more than 50 percent of ^(32)P incorporated into the phospholipid was recovered in phosphatidyl choline. When 10^(-8) I estradiol-17β was added to the reaction media the incorporation of ^(32)P-orthophosphate into phosphatidyl choline was depressed, while that into phosphatidic acid was enhanced.
These results suggest that estradiol is similar to acetylcholine in stimulating the incorporation of ^(32P)-orthophosphate into phosphatidie acid of brain cortex.

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