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家兎膀胱의 自律神經支配에 關한 硏究

The autonomic innervation of the urinary bladder in the rabbits.

전남의대잡지 1970년 7권 2호 p.83 ~ 92
차현식,
소속 상세정보
차현식 (  ) - 전남대학교 의과대학 생리학교실

Abstract


It is generally established that the urinary bladder and internal sphincter are innervated by the parasympathetic fibers from the pelvic nerve and the sympathetic fibers from the hypogastric nerve, and that the external shhincter is innervated by a perineal branch of the internal pudic nerve. However, the physiological function of these nerves on the urinary bladder is not clearly understood.
Most of previous attempts to study the innervatio of urinary bladder were mainly restricted to stimulation of the innervated nerves and cystometric measurements of intravesical pressure.
In this work, using the isolated detrusor and trigone muscles of the urinary bladder of the rabbit, action of some sutonomic drugs were studied to investigate the mode of the autonomic innervation on these structures. The results obtained are as follows:
1) By the administration of either epinephrine or norepinephrine, a marked contraction of the trigone muscle was demonstrated, and this effect was abolished completely by pretreament of phenoxybenzamine or regitine, the alpha-receptor blocking agents, whereas the effect was not affected by pretreatment of dichlorois oproterenol, a beta- receptor blocking agent.
2) By the administration of either epinephrine or norepinephrine, a marked relaxation of the detrusor muscle was observed, and this effect was abolished completely by pretreatment of dicholoroisoproterenol, whereas the effect was not diffected by pretretment of phenoxybenzamine or regitine.
3) The administration of acetylcholine produced a marked contraction of the detrusor and trigone muscles of the urinary bladder, and this effect was abolished by pretreatment of atropine, a cholinergie blocking agent.
4) These results suggest that urinary bladder is innervated by the adrenergic and cholinergic fibers, and that the adrenergic receptor in the trigone muscle is of alpha-type and the receptor in the detrusor muscle is of beta-type.

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