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개의 腎臟機能에 미치는 Chlorpropamide의 影響

Influence of chlorpropamide on the renal function of the dog

전남의대잡지 1970년 7권 2호 p.129 ~ 138
조두훈,
소속 상세정보
조두훈 (  ) - 전남대학교 의과대학 약리학교실

Abstract


In view of clinical observations that chlorpropamide, an oral hypoglycemic, has a favorable effect also in cases of diabetes insipides, the renal action of the sulfonylurea was investigated in this study.
Chlorpropamide, when given intravenously in doses ranging from 1 to 13㎎/㎏, elicited antidiuresis either during water diuresis or during mannitol diuresis, the response increasing roughly in proportion to the dose. Also, the renal plasma flow(C_(pAH) and glomerular filtration rate(C..) decreased in proportion, The decrements in osmolar clearance, uriuary excretion of sodium and free water clearance, as well as the decrease in urine flow correlated significantly with the decrease in the filtration, indicationg that the antidiuresis is effected mainly by the decrease in glomerular filtration rate by chlorpropamide, though direct action on the tubular function cannot be ruled out.
In experiments, in which the agent was infused directly into a renal artery and urines from both ureters collected separately, a small dose of 0.01㎎/㎏/min produced antidiuresis confined only to the infused side and without concomitant changes in glomerular filtration rate, inferring that the renal action of chlorpropamide is not mediated by any endogenous humoral agent, and that it has an action, though weak and masked ordinarily by the hemodynamic action, direct on the permeability of the tubules of distal portions.
During mannitol diuresis and under the influence of sufficient amount of vasopressin, chlorpropamide could not affect the reabsorption of solute-free water(T^(6)H_(3)O) suggesting that Henle´s loop and vasa recta are not influenced by it.
It is thus concluded that chlorpropamide induces antidiuresis, mainly by decreasing glomerular filtration rate, and partly by decreasing the tubular permeabilty to water in the dog.

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