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家兎에 있어서 頭蓋內壓 亢進에 관한 硏究 Experimental Studies on High Intracranial Pressure in Rabbits

전남의대잡지 1973년 10권 2호 p.377 ~ 386
서정열,
소속 상세정보
서정열 (  ) 
전남대학교 의과대학 신경외과학교실

Abstract


1. The intracranial pressure (TCP) was elevated by infusing saline solution into a balloon which was inserted into the extradural space of urethane anesthetized rabbits, and the change of ICP was registered.
2. The elevation of ICP was not apparent when the volume of the extradural balloon -was small (below about 1. 0 nil), but increasing the volume elevated ICP. When. the volume of the balloon was 2.5 to 3.0 ml, ICP was about 80 to 110 mmHg.
3. When ICP was maintained at the level of 40 to 60 mmHg for a period of 2 to 3 hours, ICP elevated. further albeit no increase of the balloon volume.
4. The hypertonic solution (mannitol) produced a prominent fall of ICP when given early period of elevated ICP, but it produced transient fall in late period of elevated ICP.
5. Increasing ICP produced arrest of respiration.
6. The arterial blood pressure increased in accordance with the elevation of ICP, but the persistent high ICP (80-110 mmHg) produced abrupt fall of the blood pressure and heart rate.
7. When ICP was maintained at the level of 40 to 60 mmHg for a period of 2 to 3 hours, the vasoactive substances (norepinephrine, angiotensin, methacholine, isoproterenol and nitroglycerin) produced rise of ICP.
8. The above experiments show that the extradural balloon method in rabbits can be utilized in study of high ICP and that elevation of intracranial pressure in the brain swelling by brain compression has intimate relationship with increase of vascular compartment.

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