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不整脈發生에 있어서의 5-hydroxytryptamine의 役割

Possible Role of 5-Hydroxytryptamine in the Development of Arrhythmia

중앙의학 1961년 1권 6호 p.637 ~ 647
김헌두,
소속 상세정보
김헌두 (  ) - 전남대학교 의과대학 소아과학교실

Abstract


Employing the electrocardiograms of the rabbit and rat, it was found that 5-hydroxytryptamine (5-HT) could produce sinus slowing or ectopic beats and potentiated the same effects induced by epinephrine. The effect of the vagal stimulation was increased by treating the animals with 5-hydroxytryptophan or giving 5-HT. The sinus slowing by 5-HT was little affected by the ligation of the common carotid artery, while the bilateral vagotomy, vagolytic substances, procaine hydrochloride and promethazine affected the sinus slowing to abolish or diminish it. it was discussed about the mechanisms of 5-HT-sinus slowing and its possibilities to participate in the development of cardiac arrhythmia.

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