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硫酸銅이 家兎血糖에 미치는 影響

Effect of Cooper sulfate on Blood sugar

중앙의학 1962년 2권 2호 p.159 ~ 166
문용식,
소속 상세정보
문용식 (  ) - 가톨릭대학 의학부 병리학교실

Abstract


Copper is known to be one of the essential trace minerals in the organisms as an integral part of some enzyme system and found utmost in the liver.
It has been well shown by Herkel, Mallory and other workers that the liver is a site of prominent storage of copper after continued administration.
Since important parts of metabolic process of carbohydrate take place in the liver, it seems to be quite possible that administration of copper would influence the blood sugar level.
Materials and methods
Albino rabbits weighing about 2kgs were used and they were infused with 0.5cc or 1.0cc of 1% CuSO4-solution per kg. b. w. intravenously.
The determination of blood sugar level was performed every 30 minutes after infusion of CuSO4-solution by Hagedorn-Jensen’s method.
To investigate the effect of copper on the state of adrenalin-hyperglycemia, the determinations of blood sugar levels were done in the animals treated with CuSO4-solution daily for 3, 5, 7, or 10 days followed by subcutaneous injection of 0.1cc of 0.1% adrenalin solution per kg. b. w.
Following results were obtained.
1. Administration of copper sulfate alone does not influence blood sugar level in rabbits.
2. Adrenalin effect on blood sugar is more prominent and transient in the rabbit$ treated with copper sulfate.
3. Such effect of copper to adrenalin-hyperglycemia appears to be kept more than 2 weeks after cessation of its administration.

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