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Adrenalin의 血液凝固促進機轉에 關하여

On the accelerating Mechanism of Blood Coagulation by Adrenalin in vivo

중앙의학 1962년 2권 3호 p.323 ~ 328
문용식,
소속 상세정보
문용식 (  ) - 가톨릭대학 의학부 병리학교실

Abstract


The accelerating action of adrenalin on blood coagulation was first noticed by Vosburg & Richards and the effect was confirmed later by many others, -however, on its mechanism their postulations were diverse. Vosburg took the increase of blood sugar by adrenalin as the cause, and Cannon & Gray claimed that liberation of accelerating element from liver into blood would bring shortening of blood clotting time, and Grabfield reported the increase of prothrombin in circulating blood.
On the accelerating mechanism of blood coagulation in vivo, our coworkers in our laboratory have confirmed that the acceleration induced by stimulants was due to the increase of serum lipids (phospholipids and cholesterol) which took part in thromboplastin generation, and were probably liberated from adrenal cortex.
Author intended to certify whether the acting mode of adrenalin was related to the adrenals and pituitary or not.
Albino rabbits weighing about 2kg were used.
Adrenalin hydrochloride was infused 0.01-mg/kg of body weight into ohr vein, and blood samples were withdrawn from juglar vein every 15 minutes for 1-2 hours after adrenalin infection. Observations were performed in 3 groups (normal, adrenalectomized, and hypophysectomized rabbits).
Determination of blood clotting time was done by Lee & White´s method.
Serum total cholesterol was calculated by Zak´s method.
Adrenals were studied hystochemically for lipids by Sudan I -staining and for cholesterol by Schultze´s test.
Following Results were obtained.
1) The accelerating effect of adrenalin on blood coagulation accompanying with increase of serum cholesterol is inhibited in the adrenalectomized or hypophysectamized rabbits.
2) Adrenalin-induces marked depletion of lipids and cholesterol in the adrenal cortex mainly in zona fasciculata from normal rabbits, but such depletion is not observed in hypophysectomized rabbits.

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