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甲狀腺이 脾臟앨러지 - 性變化에 미치는 影響에 關한 實驗的 硏究

Experimental Studies on the Influence of the Thyroid upon the Allergic Changes in the Spleen.

중앙의학 1962년 3권 3호 p.271 ~ 291
신영서,
소속 상세정보
신영서 (  ) - 육군 중앙병리연구소

Abstract

The effects of thyroid gland upon the allergic reaction on different organs ahve been extensively investigated by a number of authors.
The results were variable and sometimes conflicting and the reactions were specific to each organ. This investigation has been planned to determine the influence of thyroid upon the allegic changes in the spleen.
Material and Method : In this studies, 128 normal adult rabbits weighing around 2 kg. were used and a fresh horse serum was given as an sensitizing antigen. The rabbits were divided into the sensitized and non-sensitized and subdivided further into 4 groups, which consist of the normal, The thyroidectomized; the auto- transplanted in which transplantation of the thyroid gland was performed after thyroidectomy, and the thyroid perparation administered. Each of the non- sensitized rabbits was given one dose of 0.1 cc of normal horse serum per kg. of body weight into the parenchyma of the spleen.
In the groups of the sensitized rabbits, the sensitization has been carried out by the daily for4 days. And 15 days after the sensitization, the reinjection for provocation was given one dose of 01 cc of nomal horse serum per kg. of body weight into the parenchtma of the spleen. In the thyroid preparation administered group, the drug (Thyroid tablets : The W. M. S. Merell Company, Cincinnati, U.S.A) was daily given orally 32mgㆍ per kgㆍ body weight since 1 week prior to the sensitization. The non-sensitized and sensitized rabbits were sacrificed and resected the spleen at the end of 3, 6, 12, 24, 48, 72 hours and 1, 2 weeks after the final injection of the horse serum.
The sections were prepared by hematoxylin-Eosin, van Gieson, Bielchowsky´s and Weigert´s stains, and submitted for histological examination.
Result :
1). The allergic changes occured in the spleen of the normal rabbits by the reinjection of the same horse serum after sensitization with a horse serum.
2). The allergic changes in the spleen of the thyroid preparation administered group were severe than those in normal group.
3). The allergic changes in the spleen of the thyroidectomized group were milder than those in the normal group.
4). In the auto-transplanted group in which transplantation of the thyroid was performed after thyroidectomy, the allergic changes were almost similar in its intensity to those of normal group.
5). Thyroid gland enhances the allergic changes of the spleen of the rabbits.

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