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溫熱의 血球凝集素에 미치는 影響에 關한 硏究

Effect of Heat on Hemagglutination

중앙의학 1963년 4권 4호 p.251 ~ 267
장원룡,
소속 상세정보
장원룡 (  ) - 육군중앙의무시험소

Abstract


In the preceeding reports, the author reported a curiou serological phenomenon.
The immune sera prepared with goat or chicken red cells showed a higher hemagglutinating titers in heated state, between 72℃ and 76℃, after being diluted 10 times with saline or phenolized saline, than in ungeated state. This penomenon was referred to as heat- activated hemagglutination.
In the study, immune sera prepared with goat red cells showing geat activated hemagglutination are fractionated by means of dialysis and ammonium sulfate precipitation, and the hemagglutinating activity of each fraction is investigated.
Heat-activated hemagglutinating antibidies are found to be contained chiefly in the water-soluble globulin fraction of sera, but become water-insoluble when sera are heated at 72℃for 30 minutes before fractination. A small amount of antibodies are also found in the water-soluble fraction of sera.
The activity of sera heated at 56℃ for 30minutes is equally divided into both fractions if euglobulin and pseudoglobulin after fractination. However, euglobulin fraction of sera geated at 72℃ shows much higher hemagglutinating activity than pseudoglobulin. Euglobulin and pseudoglobulin fracitons derived from unheated sera show the phenomenon which the author call heat-activated hemagglutination when heated at 72℃.
Between these two fratctions, pseudoglobulin shows much higher titer than euglobulin. Alubumin fration dose not show any immunological activity.

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