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人蔘이 Histamine의 毛細血管 透過性 亢進作用에 미치는 影響에 關한 硏究

Studies of the effects of Ginseng on the augmented permeability of capillaries induced by histamine

중앙의학 1963년 5권 3호 p.235 ~ 240
김혜성,
소속 상세정보
김혜성 (  ) - 이화여자대학교 의과대학 약리학교실

Abstract


Ginseng has been used among oriental people centuries for therapeutic purpose of various kinds diseases, but the pharmacological foundation for its use has not been fully elucidated. Recently, Lee and his collaborators have probed that ginseng extract contains a component which releases histamine. whang observed that prior administration of antihistaminics prevented the edema produced by the administration of ginseng extract.
This experiment was undertaken to clarify the influence of ginseng upon the augmented permeability of capillaries by histamine.
Method :
The ginseng employed in the present studies is the white ginseng root, five years old, grown in Keumsan, Korea. The water extract was prepared according to they official method: one milliliter of this extract is equivalent to 0.5 grams of ginseng root.
The effects of drugs on the capillary permeability was determined according to the procedure described by Miles and Miles. Thus, the changes in capillary permeability to trypan blue in rats were judged by the degree of bluing in skin areas where agents were administered intradermally. Three days following depilation of the back of rats, 10 mg of trypan blue was administered intravenoulsly. Following dye administration, drugs dissolved in 0.9 per cent sodium chloride were injected intradermally in a volume of 0.1 ml. The animals were killed 10 minutes later and the skin= removed for viewing or photographing.
Results :
1) Following intravenous administration of trypan blue into normal rats, the intradermal injection of 0.005 7 of histamin phosphate produced essentially no bluing. However, the injection of 0.01 7, 0.05 7 and 0.1 7 of histamine produced a significant bluing of the skin in 15, 40 and 66% of rats respectively.
2) In rats fed orally with ginseng extract in a daily dose of 5 ml/kg for 3 days, the intradermal injection of histamin 0.01 7 and 0.1 7 produced a noticeable bluing of the skin in 31 and 75% of animals respectively. It is interesting to note that slight bluing was detected in some of these rats following the injection of 0.005 7 of histamine, which produced no bluing in normal rats.
3) In rats fed orally with ginseng 5 ml/kg for 6 days, the bluing of the skin following the injection of 0.005 7, 0.01 7 and 0.17 of histamine was observed in 72, 74 and 88% of rats reapectively.
4) In rats fed orally with ginseng 5m1/kg for 9 days, the bluing of the skin folio-wing the injection of 0.005 7, 0.017 and 0.1 7 of histamine was observed in 82, 86 and 94% of animals respectively.
From the above experiments, it may be concluded that the effects of histamine on the permeability of capillaries in rat skin to trypan blue was maskedly enhanced by pretreatment with ginseng. This result appears to support the view that ginseng extract contains a component which releases histamin. Further experiments, however, would be required to prove this view.

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