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Flavin 代謝에 미치는 各種藥物 및 Ehrlich 腹水癌의 影響에 關한 硏究

Flavin Metabolism In The Rats And Mice Given Various Drugs, And Inoculated With Tu

중앙의학 1963년 5권 6호 p.679 ~ 694
채범석,
소속 상세정보
채범석 (  ) - 서울대학교 의과대학 생화학교실

Abstract


To make a study on the metabolism of flavin in the hepatic and renal tissues of rats or mice, the following four conditions were given,
Carbon tetrachloride (CCI₄) : By the intramuscular injection of CCI₄ in tow different ways, acute and chronic liver cell damage was produced; the acute liver cell damage by single dose of 5.0rn1 per kg. body weight of 20% CCl₄ olive solution and the chronic one by repeated injections with weekly dose of 2.0ml per kg. body weight for 8 weeks. To those rats with acute and chronic liver cell damage, three dietary conditions were given further, namely, standard diet (control), thiamine loaded and riboflavin loaded diet.
were fed by three different diets, namely, control, riboflavin deficient and riboflavin loaded diet.
Ehrlich ascites carcinoma cells : By inoculating Ehrlich ascites carcinema cells, cancer was induced to mice which were fed by the three different diets of which contents are the same with those for the mice that were given antibiotics.
Antineoplastic drugs :Thio-TEPA, (2.0mg/kg body weight), Cytoxan(50mg/kg body weight), 8-azaguanine (50mg/kg body weight) 6-azauracil (50mg/kg body weight) and 5-bromouracil (50mgfkg body weight) were given for 7 days h intraperitoneally to the mice which were fed with standard (control) diet.
Following results were obtained.
1) Marked decrease of total riboflavin and FAD content, and increase of FiA-I? and FR content in the liver and kidney of the rats were observed at the second day after injection of single large dose of CCI₄, decrease of total riboflavin and FAD content, and slight increase of FAIN and FR content, were observed by repeated by repeated injection of small dose of CCI₄. But the change of riboflavin content was not so marked as in the rats with acute liver damage, The most marked decrease of total riboflavin and FAD content occurred in riboflavin deficient -group, but no great change of total riboflavin and FAD content was made by thiamine or riboflavin loading as compared with that of normal diet group.
2) All the antineoplastic drugs used in duced a decrease in total riboflavin and FAD content, but an increase in FMN and FAD content in the mouse liver and kidney. The most marked decrease of total riboflavin and FAD content occurred in 8-azaguanine administered group.
3) The inoculation of cancer cell made the decrease of total riboflavin and FAD content and increase of F ,4N and FR in the mouse liver and kidney.
4) All the antiboiotics used produced a decrease of total riboflavin and FA; co ntent, but an increase o f FMN and FR in the liver; a decrease of FMN, an increase of FR and no considerable change of FAD in the kidney of the mouse. The most marked decrease of FAD content was observed in riboflavin deficient group, but no great difference in riboflavin pattern was observed between standard diet group and riboflavin loaded one.

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