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Picrotoxin 痙攣에 對한 Chlorpromazine의 影響

Effects of chlorpromazine on the picrotoxin-convulsion

중앙의학 1963년 5권 6호 p.695 ~ 698
진영주,
소속 상세정보
진영주 (  ) - 전남대학교 농과대학 수의학과 내과학교실

Abstract


About the effects of intraperitoneally injected chlorpromazine (given30 minutes prior to picrotoxin) to both the time reguired for` the onset of convulsion and´ the rate of death of mice by the intraperitoneal injection of picrotoxin(5xpg/kg), the following results were observed.
(i) Small-amount of chlorpromazine (0.2 neg./kg)´,shortend the time rgnireed for the onset, of ´the picrotoxin-convulsion significantly without giving any effect to the rate of death.
(ii) Moderate amount of chlorpromazine (1mg/kg) showed no effect on the picrotoxin-cov ulsnion.
(iii) Large amount of chlorpromazine (5mg/kg- 20mg/kg) prolonged the´ time required for the onset of convulion and at the same time decreased the rate of death significantly.

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