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Ca의 腸管內 吸收에 關한 實驗的 硏究

Experimetal Studie on the Intestinal Absorption on Calcium

중앙의학 1964년 6권 5호 p.549 ~ 554
김희철,
소속 상세정보
김희철 (  ) - 경북대학교 의과대학 산부인과학교실

Abstract


It is well known that Ca is absorbed in the upper part of small intestine and various factors are influenced the absorption.
Prevously, several experiments about the factors influencing of Ca absorption have been reported.
But all of them applied the indirect methods of calculation though giving the nutrients by mouth or injection of Ca salts.
Above experiments, It is hard to gain the real degree of the intestinal absorption and find out inhibitory factors upon the absorption.
In this paper, the direct method was applied; Cutting of a small intestine from the plica duodenojejunalis with the length of 30cm though this operation much attention were paid in avoiding the impairment of the blood vessels and lympatics. After charging the dissolved substances in buffer solution of pH 6,6 to the separated part of the intestine, calculation were made upon the absorption of Ca in a certain time.
And observed the amount of Ca absorbed by intestine when Ca solution were charged with sugars, organic acids, vitamins, and the influences @f various pH.
The results of experiments are summerised as follows:
1) The rate of Ca absorption is enhanced during first one hour but limited within some degree.
2) When the concentratin of Ca is high, more Ca is absorbed by the gut than low concentration is used, but this increaced absorption is not proportional to its concentration.
3) pH value of 5.0 and 0 showed the favorabl for Ca absorption.
4) Vhonosaccarides such as glucose, fructose seemed no influence on Ca absorption.
5) Various kinds of organic acids show irigenerally inhibitory action upon the absorption, especially oxalic acid is more prominently.
6) Various kinds of vitamins have different effects on Ca absorption, vitamin A & D, B₂, K₃, promote, vitamin Br on influence and vitamin C inhibit.

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