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肺結核患者 血淸의 抗菌力에 關한 硏究

Studies on the Antibacterial Activity in Sera of Lung Tuberculosis Patients

중앙의학 1964년 7권 4호 p.455 ~ 465
기의식,
소속 상세정보
기의식 (  ) - 제3陸軍病院

Abstract


The antibacterial substances in sera of normal and sick individuals is known to be present from the early days of serology. These substances are proved to be attributed to the complement, prorerdin, non-specific and specific antibodies, undialysable substances, and other serum components, and divided into two groups. A group of substances is active against Gram positive bacteria and relatively heat-stable and the second group is active against Gram negative bacteria and healabile. The nature of these substances are widely investigated, but the distribution in sera- of various diseases is not well understood.
The author is interested in the variation of non-specific antibodies and antibacterial activity _in sera of lung tuberculosis during the progress of disease, and studied Widal reaction with H and 0 antigens of S. paratyphi A, S. paratyphi B and S. typhi. The antibacterial activity of sera was also studied with Staphylococcus albus (coagulase negative) and and S. typhi H901.
The follwing results were obtainned.
1. Geometric mean of H antibody titer of S. typhi was 49, 5 (titers were expressed as the reciprocal of serum dilutions), while titers of other test organisms were around 20. The 0 antibody titers to three test organisms were very low. Therefore, only H antibody titer of S. typhi was evaluated as the results of Widal reacton.
2. Sera of patients who were inoculated-with TAB vaccine ,within a-years howed, a higher mean Widal titer than those inoculated before one year.
3. Patients in active state-showed a ,higher mean Widal titer than those in quiescent state. and far and moderately advanced patients =showed higher Widal titers than minimal cases.
4. There was no difference in Widal titer by the difference in body temperature.
5. Patients with ESR levels-of 11-25 showed a lower Widal titer than those with-ESR levels of less than 10 and. more than 26.
6. H agglutinin of S. typhi in sera of tuberculosis patients was absorbed by treating sera with 0 antigen of S. typhi, while H antibody in sera of typhoid patient was not absorbed with 0 antigen of S. typhi.
7. Mean titers of antibacterial activity against Staphylococcus and S. typhi were-17.2 and 19, 3, respectively.
8. Patient of f ibr-onodul ar type showed a little higher mean antibacterial titer than those of fibro-caseous and exsudative caseous types, and minimal cases showed a higher titers than. moderately and far advanced cases.
9. Patient without night sweating showed a little higher antibacterial titers than those with night sweating. Patients with low ESR level also showed a slightly higher titer than those with high ESR level.
10. The duration of treatment with anti-tuberculosis drugs does not effect on the antibacterial activity.
11. Patients with Widal titer of 40 showed a slightly higher antibacterial activity than those with Widal titer of 80.
12. The antibacterial activity of sera against Staphylococcus and S. typhi paralleled in most cases, but the variation of mean titers against S. typhi in various conditions of disease was generally more evident than those against Staphylococcus.

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