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여러가지 方法에 依하여 家兎體內에 注入한 葡萄狀球菌 phage의 動態에 對하여

Studies on the movement of Staphylococcal phage introduced into rabbit body by various methods

중앙의학 1964년 7권 5호 p.595 ~ 601
하대유,
소속 상세정보
하대유 (  ) - 전남대학교 의과대학 세균학교실

Abstract


The anthor has studied on the movement and condition of Staphylococcal phage introduced into rabbit body by various methods and obtained the following results.
The phage particles introduced into peritoneal cavity of rabbit were recovered from blood and, according to the progressing of time, the phage has gradually disappeared from blood, At this time, if phages were introduced into peritoneal cavity of the rabbit blocked previously all the Reticuloendothelial System and the phage for introducing into peritoneal cavity was diluted with distilled water, physiologic normal saline and normal saline plus 10-3M magnesium solution, no any special finding was observed during movement of the phage form peritoneal cavity to blood.
After inoculation of phage particles into peritoneal cavity of rabbit, more phages were recovered from the liver and spleen for the longest time, much phage particles have moved into urine and the phage was also demonstrated in stool.
The phage particles administered orally into rabbit body were recovreed from blood and stool.
The phage particles can pass through the placental barrier of rabbit and the phage injected into the ear vein of pregnant rabbit was recovered from the fetus.
In subcutaneous tissue spare of rabbit, the phage particles can not be freely moved out and, according to the progressing of time, the phage was easily inactivated.

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