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同種大動脈瓣膜移植에 關한 實驗的硏究

An Experimental Study on Homologous Aortic Valve Graft

중앙의학 1965년 8권 5호 p.551 ~ 558
강중구,
소속 상세정보
강중구 (  ) - 서울대학교 의과대학 외과학교실

Abstract


Microscopic study was done on the homologus canine aortic valve graft inserted ttransperitoneally into the infrarenal abdominal aorta.
Homograft was prepared with stepwise one or two aorta cuffs at each end ,of the valve to decrease internal diameter and to facilitate vascular anastomosis, (Fig. 2)
Prepared graft was sterilzed and preserved in 75% alcohol for one to 4 months before experiment and washed thoroughly with saline before grafting.
Animals were sacrificed and grafted specimens were examined. 1, 2, 3, 4 and 5 months after graft operation.
Among 30 grafted animals there were ten operative mortality. Postoperative hemorrhage due to suture insufficiency was the main cause of death.
1) In almost all dogs that survived more than one month thrombosis in the aortic sinus was noted.
2) Except two cases the cusps were soft and in good shape.
3) Grafted specimens were embedded in a dense fibrous connective tissue capsule and firmly incorporated into the neighboring host´s tissue.
4) In one month specimen hemorrhage, thrombosis, focal necrosis, and acute inflammation were noted.
5) In two to three months specimens repairing processes, i.e small round cell infiltration, calcification and fibrous connective tissue proliferation were noted.
6) Complete endothelialization of the aorta and valve cusps were noted in the four to five months specimens.
This experiment shows that complete repair of grafted homologous aortic valve occurs in five months.

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