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血淸 및 肝組織 Malic Dehydrogenase活性에 미치는 肝損傷의 影響

Effect of Liver Injury on Serum and Liver Malic

중앙의학 1967년 12권 4호 p.379 ~ 385
李震淳, 李璟泰,
소속 상세정보
李震淳 (  ) - 서울대학교 醫科大學 生化學敎室
李璟泰 (  ) - 서울대학교 醫科大學 生化學敎室

Abstract


Male adult rabbit was subjected to investigate the interrelationship between serum and liver malic dehydrogenase activity following experimental liver injury.
Liver injury was performed by 2 kinds of operation, one was partial ligation and the other was partial hepatectomy at 1/3 portion of left liver lobe. One 2.3 and 4 days after operation, 10 rabbits out of each group were sacrificed respectively and remaining liver tissue was taken out for enzyme assay.
Blood drawn before operation and resected liver tissue by partial hepatedctomy were used for control experiment.
Matic dehydrogenase activity was determined by the method of Porter(45) and Bodansky (46) using serum and 10xliver homogenate. The result of this investigation was as follow.
1. The serum malic dehydrogenase activity of liver injured rabbit was increased significantly and reached maximum peak at the next day after operation (ligated group; 257.5% and resected group; 278.1% of control) followed by sharp decrease and reached around the preinjured state.
2. The liver malic dehydrogenase activity of liver injured rabbit was also increased and reached maximum peak at the next day after operation (ligated group: 227.5%, resected group, 268.5%) followed by sharp decrease and returned to preinjured state
3. From the data; thus obtained, the author concluded that the increase of serum malic dehydrogenase of liver injured animal was originated in the liver enzyme which was increased compensatorily due to liver regeneration but not due to the leakage out of necrotized liver tissue.

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