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甲狀腺이 免疫形成에 미치는 影響에 關한 實驗的 硏究

Experimental Studies on the Influence of Thyroid Gland upon Antibody Formation in the Rabbit

중앙의학 1967년 12권 5호 p.481 ~ 496
박혁석,
소속 상세정보
박혁석 (  ) - 서울위생병원 산부인과

Abstract


The occurence of pyroninophilic cells is well corelated with antibody formation from cellular source. Cytoplasm, with evidence of RNA-containing granules play an important role in biosynthesis of protein, especially gamma globullin that imposed as a major component in the formation of immune response.
The present experiment was carried out in order to investigate the influence of thyroid gland upon antibody formation as reflected by the presence of pyroninophilic cells in various organs of the rabbit following antigenic stimulation with horse serum.
The experimental animals were grouped into 10 groups, and each group denoted as following;
Group "1. Normal rabbits.
“2. Rabbits with immunization with horse serum.
“ 3. Rabbits with sham operation.
“4. Rabbits with immunization and simultaneous sham operation.
“5. Rabbits with thyroidectomy.
“6. Normal rabbits with administration of thyroid extract.
“7. Rabbits with immunization and thyroid extract administration.
“8. Rabbits with immunization and thyroidectomy.
“9. Rabbits with thyroid extract administration following thyroidectomy.
“10. Rabbits with immunization, thyroidectomy and thyroid extract administration.
The results were summarized as follows:
1) The grade of pyroninophilic cell infiltration in the lymphnode and the spleen of group 7 was slightly greater than that observed in group 2.
2) In group 8, the odcurennce of pyroninophilic cell in both the lyhiphnode and the spleen was greater than that observed in group 2, and the finding was highly assimilated with that observed from group 7. However, the inclination of pyroninophilic cell distribution was noted in the lyniphnode in group 8, and group 2 in the spleen.
3) A moderate degree, of pyroninophilic cell infiltration was noted in group 4, meanwhile with lesser extent than group 7 and 8, However, the extent was greater than group 2.
These findings, therefore, highly suggested the fact that thyroid gland did neither involve itself in the process of acceleration or suppression of antibody formation constantly but to produce a certain influence upon it.

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