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右心房璧 移植에 關한 實驗的 硏究

Experimental Study on Patch Graft of the Right Atrial Wall

중앙의학 1967년 13권 5호 p.455 ~ 464
김원필,
소속 상세정보
김원필 (  ) - 서울대학교 의과대학 외과학교실

Abstract


Macroscopic and histological studies were done on the canine right atrial patch grafts. Fresh autogenous and alcohol prserved homologous pericardium, dacron, and compressed.
ivalon sponge patches were grafted into the right atrium to expand the atrial cavity.
One, two, three, and four months specimens were obtained from each patch group off
long term survivors. .
Macroscopic findings:
Among twenty long-term survivors an .organized thrombose was found on the intimal surface of the homologous pericarduim and decron patch, which were one month old.
In one month old specimens, intimal surfaces were ragged and rough, while after two months every specimen showed smooth and glittering endocardial surface except homologous pericardiums.
There was no evidence of aneurysmal dilatation of thee grafts.
Shrinkage of the graft was almost absent in ivalon and remakeble in the homologous pericardium group.
Microscopically: .
One month group showed mainly neutrophile polymorphnuclear leucocyte infiltration, indicating acute inflammatory processes. .
Two to three months old groups of the specimens showed subsiding acute inflammatory signs and repairing processes with marked small round cell infiltration, fibroblast, and fibrous connective tissue proliferation in and around the patches.
In four months specimens fibrous connective tissue capsules were incorporated into the hosts’ myocardium firmly, and in most of them endothelialization of the intimal surfaces of these connective tissue capsules were noted.
Among these four kinds of patch groups dacron showed the most and autogenous pericardium the least severe tissue reactions.
In this right atrial patch graft experiment it was shown that the grafts healed satisfactorily in four months.

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