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갑상선 적출 토끼의 조직 저장철에 관한 연구

Studies on the Tissue Storage iron of Thyroidectomized Rabbits

중앙의학 1968년 14권 2호 p.149 ~ 172
김기협,
소속 상세정보
김기협 (  ) - 부산대학교 의과대학 산부인과학 교실

Abstract


The author observed changes of the storage iron content in the thyroidectomized rabbits. The two forms of the storage iron, ferritin and hemosiderin, were estimated with methods of Yoneyama-Konno and Bruckmann-Zondeck.
From the results thus obtained, he reached the following conclusions.
1. In the thyroidectomized animals, the ferritin iron of the liver and spleen increases at one time. This is thought to be a transitory reaction to the blood loss during the operative procedure of thyroidectomy.
2. The storage iron content of the liver, spleen and renal cortex in the thyroidectomized animals decreases linearly from 3 to 6 days after the operation, and the ratio of ferritin iron/hemosiderin iron increases for a definite time postoperatively. After the postoperative decrease, there is a tendency to maintain a constant level of storage iron, and the ratio of both fractions of the storage iron tends to return to normal.
3. In the thyroidectomized animals, the renal medulla and bone, marrow show a tendency to diminish the storage iron content, and no constant ratio of both iron fractions.
4. The storage iron content, especially ferritin fraction, of the duedenum decreases later in the postoperative days. The ratio of both iron fractions also decreases as the storage iron decreases.
5. Although the mechanism concerning the diminution of the storage iron in thyroidectomized animals is not clearly understood, it is thought that one of the important factors is decreased erythropoiesis due to impaired absorption of iron from the gastrointestinal tract.

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