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Septal area, Hippocampus, Amygdala 및 Midbrain이 血糖代謝에 미치는 影響에 關한 實驗的 硏究

Experimental studies on the Influences of the septal area, hippocampus, amygdala and midbrain upon the blood glucose metabolism

중앙의학 1968년 14권 6호 p.497 ~ 513
이형주,
소속 상세정보
이형주 (  ) - 서울대학교 의과대학

Abstract


Since Aschner observed the hyperglycemia after the lesion in the hypothalamus there were many reports concerning the relationship between blood glucose metabolism and the function of the hypothalamus. And Rie et al reported recently that the anterior hypothalamus has the function as a glucoreceptor. As the hypothalamus has the afferent connections with septal area, hippocampus, amygdala and midbrain by the nerve fibers, I investigated that whether these areas have some influences upon the blood glucose metabolism.
In order to utilize Choi´s brain atlas, I used 1. 8kg. body weight Korean white male rabbits.
The rabbits were fasted for from 12h. to 16h. before experiments. I chose 30 gauze injection needle in order to avoid the mechanical stimulation as much as possible by its puncture 0.05cc. of physiologic saline, 20% glucose solution, destilled water and 3% hypertonic saline were injected in the above areas bilaterally by stereotaxic instrument and I observed the subsequent changes in blood glucose level.
Blood glucose contents were determined according to Somogi-Nelson micromethod.
The results were as follows;
1) By the stimulation with 30 gauze needle puncture in the septal area, hippocampus, amygdala and midbrain in each group of 3 rabbits slight hyperglycemia resulted which increased as much the blood glucose levels as 31 mg%, 13mg%, 17mg% and 29mg% higher than those of before the puncture respectively. And these hyperglycemia maintained almost same level for 12 min after the puncture.
2) The injections of physiologic saline in the septal area in 6 rabbits, followed slight hyperglycemia and the blood glucose level was as much 22mg% higher than those of before injections; the injection of 20% glucose solution in the same area in 8 rabbits also increased the blood glucose level as much 23mg% higher, while the injection of distilled water in the same area in 6 rabbits caused marked hyperglycemia and the blood glucose level rise as much 90mg% higher than those of before injection respectively.
3) When injected the physiologic saline in the hippocampus in 4 rabbits the blood glucose level increased as much 58 mg% higher than those of before injection, but the injections of distilled water in 5 rabbits and 20% glucose solution in 5 rabbits in the same area, the blood glucose level increased 32mg% and 6mg% respectively than those of before injections.
4) The injections of physiologic saline in 5 rabbits and 20% glucose solution in 6 rabbits in the amygdala showed slight increase of the blood glucose levels as much 31..6mg% and 14.3mg% higher, while the injection of distilled water in 5 rabbits in the same area the blood glucose level markedly increased as much 94.8mgo% higher than those of before injections respectively.
5) When injected physiologic saline in 5 rabbits, 20% glucose solution in 5 rabbits and distilled water in 5 rabbits in the midbrain, the blood glucose level showed slight increase such as 16.4mg% 25.4mg%, and 21.6mg% respectively than those of before injections.
6) When injected 5u. of insulin intramusculary and injected distilled water in the septal areas in 6 rabbits at the same time, the blood glucose level showed slight increase 5min. later such as 35mg% higher than those of before injection and then reduced continuously, while the injection of 5u. of insulin alone in the same area in 3 rabbits intramusculary the blood glucose level showed continuous reduction after injection.
7) When injected the 20mg% of dibenamine (sympathicus blocking agent) intramusculary and injected distilled water in the septal area in 5 rabbits 30 min later, the blood glucose level rise as much 68.6mg% higher than those of before injection, while the injection of 20mg% dibenamine in 5 rabbits intramusculary showed slight increase of the blood glucose level such as 38mg% higher than those of before injection.
8) The injections of 3 % hypertonic saline in the septal area in 5 rabbits and in the amygdala in 5 rabbits showed marked ´increase of the blood glucose level such as 86mg% and 70mg% higher than those of before injection respectively.
Therefore, I concluded from above results that marked hyperglycemia resulted from the injections of distilled water and 3% hypertonic saline in the septal area and amygdala of the rabbit shows these areas have some functional relationship between blood glucose metabolism.

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