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복수암세포 lactic dehydrogenase isozyme 활성에 대한 항암제의 억제작용에 대하여

On The Effects of Anti-Tumor Agents on Lactic Dehydrogenase Isozymes of Sarcoma-180 Ascites Cells

중앙의학 1968년 15권 4호 p.283 ~ 288
정기홍,
소속 상세정보
정기홍 (  ) - 가톨릭의과대학 산부인과학교실

Abstract


1) The author in the present paper, investigated the inhibitory effects of 6-mercapto-purine and 5-fluorouracil on the activities of lactic dehydrogenase and its isozymes, H-and M-LDH respectively, to find out that these anti-tumor agents exerted selective action towards the 2 isozymes.
2) Both of the agents inhibited the activity of LDH of the Sarcoma-180 ascites cells, the effect exerted by 5-fluorouracil being far greater than the effect displayed by 6-mercaptopurine.
3) Both of the agents showed the inhibitory effects on the LDH isozymes, but the inhibition of M-LDH was more pronounced than the inhibition of H-LDH by both of the agents.
4) 5-Fluorouracil showed more marked inhibitory effect on the M-LDH than 6-Mercaptopurine.

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