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家兎血淸의 Candida種 發育抑制作用에 關한 硏究

The Growth Inhibitory Action of Normal Rabbit Serum on C. Albicans

중앙의학 1968년 15권 5호 p.417 ~ 427
서동익,
소속 상세정보
서동익 (  ) - 경북대학교 의과대학 세균학교실

Abstract


Increasing use of antibiotics, antimetabolic drugs and steroid hornnone has made a untoward predilection for the contraction of candidiasis, especially unrecognized clinical cases are of practical importance in association with the reduction of defense mechanism and growing concerns are directed toward the handling of debilitated patients.
Anticandidial effects or the resistances of the host against infection are expressed by non specific character rather than specific or immunologic ones that the role and the significance of immunity of the patient are obscure in nature as compare to usual bacterial infections.
For the purpose to evaluate these non specific resistance experimentally, author designed to study the anticandidial effect of normal rabbit sera and checked the various factors which will influence the effects.
Among the sera of each rabbit, no significant difference in activity was observed, however, there were marked difference in inhibitory action according to the composition of media, the more suitable for the growth of yeast or sugar added, the more the inhibitory action was reduced, and there were no strain difference in sensitivity to sera but fundermental distinction in action was existed between serum and whole blood.
The inhibitory action of sera was destroyed by heating and absorbed by zymosan, but digestion by trypsin and inactivation by alcohol were not clear in results.

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