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Cholesterol 投與가 白鼠血淸 및 肝組織內 各種 酵素活性에 미치는 影響

The Effect of Cholesterol-feeding on Various Enzyme Activies of Serum and Liver Tissue of Rats

중앙의학 1969년 16권 1호 p.71 ~ 80
庾定鎬, 成樂應,
소속 상세정보
庾定鎬 (  ) - 서울대학교 醫科大學 生化學敎室
成樂應 (  ) - 서울대학교 醫科大學 生化學敎室

Abstract


The changes in total cholesterol level, beta-glucuronidase and transaminase activities, vitamin B6 level and alkaline phosphatase activity were each traced in the serum and liver tissue of the rats prior to and 2, 4 and 8 weeks after the administration of standard diet. containing 1, cholesterol to the animal. The results obtained were as follows.
1. The total cholesterol level in the serum rose from 67±7mg% of control to 215± 17mg% at the 8th week on cholesterol feeding:in the liver the rise was from 2. 56 ±0. 1mg. /g w. w. to 11.05±1. 05mg. /g w. w.
2. The cholesterol biosynthetic activity of the liver as measured by acetate-l-C-14 incorporation was considerably depressed by exogenous cholesterol i.e., from .1985 cpm/g. of control to 115 cpm/g. at the 8th week.
3. Both in liver and serum the beta-glucuronidase activity increased until the 4th week, then decreased rapidly at the 8th week on cholesterol-diet.
4. In the liver both GOT and GPT activities were stationary, whereas in the serum a gradual elevation of the enzyme activities were noted. On the other hand the serum and liver contents of vitamin B6 which has to do with the transaminase activities, were lowered.
5. The alkaline phosphatase activity of the serum and liver was gradually increasing
on the administration of cholesterol diet.

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