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ʦ ʫ 17-Ketosteroid ܨ Chlorpromazine

Influences of Various Visible Rays on the Urinary Excretion of 17-Ketosteroid in Rabbits and the Effect of Chlorpromazine Upon these Influences

ֽ 1959 2 4ȣ p.15 ~ 20
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Abstract


The wide use of glamercus illumination in architecture and the overexpeure oi the human bode to the lighting has fecuscd aitcrition on ex? rim ental works to find some biological changes which rn.g -t occur by various visible rays.
Since Messer first described in i943 that the functional changes of the autonomic nervous system are caused by certain visible rays, many works have accumlated to indicate that animals flashed with a red visiblc ray develop parasym pathicotony, while do the flashing with a blue ray sympathicotony.
Based on these facts, this experiment was attempted to find out bodily functional changes to be caused by various visible rays through the quantitative measurement of 17-ketosteroid in urine.
17-ketosteroid is one of metabolites of corticoid excreted in urine and if the light act as a kind of extrinsic stresses, it might cause easily oversecretion of ACTH in the pituitary glands by which stimulates the adrenal cortex. In experiment, the various visible rays as classified with blue, green, yellow,and red were flashed to rabbits.
The rabbits were devided into 3 groups; the 1st was the group irradiated with various rays. the 2nd was the group irradiated after administration of chlorpromazine and t,o-d vhiis the contrr: flashed with the natural compound ray.
The results can be summarized as :c flows
1. The urinary excretion of 17-Ketosteroid rabbits increased to a significant degree by the irradiation with various visible rays as compared with rabbits under the natural compound ray
2. The values of 17-Ketosteroid In urine varied ac-cording to the wave-length of the light, this seems to indicate that there exist some difference in the intensity of light stresses caused by each isolated single ray.
3. The irradiation of various visible rays has given no change in the value of 17-ketosteroids in Urine of the rabbit, previously injected with chlorpromazine. This indicates that the light stress can be blocked by administration of chlorpromazine.

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