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甲狀腺이 膀胱의 알러지에 미치는 影響에 關한 實驗的硏究

Exparimental Studies on the Influence of tne Thyroid Gland upon the Allergic Changes of Urinary Bladder

최신의학 1960년 3권 9호 p.115 ~ 137
유동윤,
소속 상세정보
유동윤 (  ) - 연세대학교 의과대학 병리학교실

Abstract


In, the past there have been many reports on the
influence of endocrine glands upon the organic tized and was used as the.control.
However, there has been no A single injection , of normal horse serum
experimental work of the urinary bladder.
Under the guidance of prof. I. S. Yun, a series
of animal experiments has been carried out to
determine the influence-of thyroid gland upon the
allergic changes of the urinary bladder.
Materials
Rabbits, "weighing approximately 2 -kg " were used. The antigen used was fresh horse serum prepared by the Korean National Instityte of Preveation
of, Insfection Diseases, and medicated the thyroxin tablets (Chase Chemical Comp.) orally as the thyrold gland products.
Methods
The experimental animals were devided into
7 groups, In order to see the effects, of thyroid
gland, thyroxin 0.2g per. kg of body weight was
given orally every day.
1). Non-senitized group-This group was not sensi-
allergic changes. 0. l,cc per kg of body weight was injected into
the serous wall of Trigonum vesicae.
2) Sensitized group-in normal rabbits, normal
horse serum 1.Occ per kg of body weight was
injected subcutaneously into the abdominal wall
Materials once daily for 4 days. 2 weeks after the sensiti-
zation, reinjection was carried out in the foll-
owing. manner normal horse serurn Q.lcc per kg of ´body weight was injected into the urinary bladder and was used as the control.
3). Thyroidectomized group-After the thyroidectomy sensitization and reinjection was performed like the 2nd group.
4) Thyroid transplanted group-After the thyroid transplantion, sensitization and reinjection was carried out in the same manner.
5). Thyroidectomized and thyroid autotransplanted group-After the thyroidectomy, the thyroid gland was autotransplanted, and the sensitization and reinjection were same.
6). After the thyroidectomy thyroxin administered group-After the thyroidectomy and sensitization thyroxin was administered orally through the examination.
7).. Thyroxin medicated group-By the sensitization thyroxin was administered orally through the examination.
Results
1) Severe allergic changes. occurred on the urinary bladder wall with the reinjection of horse serum into the urinary bladder wall after sensitized rabbits with the"same horse serum.
2) Thee allergic changes are milder in the thyrodectomized rabbits than. in the normal rabbits.
3) Severeallergic changes occurred in the rabbits, which were fed with Thyroxin than in the normal rabbits.

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